Nelson D. Goldberg BMBB Faculty 1987- 1999

Nelson D. Goldberg
Lectureship Series

9th Annual Lecture
Dr. Christin Carter-Su, University of Michigan Medical School, Ann Arbor, MI
The Role of the Tryosine Kinase JAK2 in Actions of Growth Hormone.

Wednesday, February 20, 2008
4:00-5:00 pm
2-137 Jackson Hall

Background
Nelson D. Goldberg received his B.Sci. in 1953 from the University of Toledo and following military service at Walter Reed Army Institute of Research, a Ph.D. in 1962 from the University of Wisconsin. He conducted postdoctoral studies with Oliver Lowry at Washington University School of Medicine and moved to the University of Minnesota in 1964 as an Instructor in Pharmacology. He moved quickly through the academic ranks, becoming Professor of Pharmacology in 1972 and Professor of Biochemistry in 1987. His energy and enthusiasm for science were evidenced through his diverse research interests in the area of signal transduction and metabolic control. During his 40+ year career, he studied TCA-cycle intermediates in the brain, effects of insulin on cyclic nucleotide metabolism in the muscle, and hormonal control of glycogen turnover in the liver. Perhaps his most noteworthy studies were on the synthesis and metabolism of cGMP and its relationship to cAMP mediated signaling events. He demonstrated regulated synthesis of cGMP in response to cholinergic stimulation and developed analytical methods to measure not only the synthesis of phosphorylated molecules, but also their degradation. His interest in "high-energy" phosphoryl compounds continued into the 1990's as he studied the role of adenylate kinase in phosphoryl transfer reactions.

Goldberg Lectures

Year	Speaker/Affiliation	Title
2000	Dr. David Garbers UT Southwestern Medical Center, Dallas
2001	Dr. Tony Hunter The Salk Institute, La Jolla	Cellular Regulation by Phosphorylation and Ubiquitination.
2002	Dr. G. Stanley McKnight University of Washington, Seattle	Physiological Functions of Protein Kinase A.
2003	Dr. M. Daniel Lane Johns Hopkins School of Medicine	The Malonyl-CoA Hypothesis and Regulation of Energy Metabolism.
2004	Dr. Morris J. Birnbaum University of Pennsylvania	The Coordinated Control of Growth and Metabolism.
2005	Dr. Barbara B. Kahn Harvard Medical School, Boston	AMP-Activated Protein Kinase: Ancient fuel Gauge is a Key to Modern Understanding of Metabolism.
2006	Dr. Christopher B. Newgard Duke University, Durham	Comprehensive Metabolic Analysis to Identify Mechanisms of Diabetes and Obesity.
2007	Dr. George Thomas University of Cincinnati, Cincinnati	Nutrient Sensing in the mTOR/S6K1 Signaling Pathway.
2008	Dr. Christin Carter-Su, University of Michigan Medical School, Ann Arbor, MI	The Role of the Tryosine Kinase JAK2 in Actions of Growth Hormone.